Sedating and non sedating antihistamines dating sites brantford ontario

General practitioners are also asked to indicate whether the event was considered to be related to the drug, although they are not required to make this connection.Additionally, the prescribers are asked to indicate whether the drug has been stopped and, if so, the reason for this.It has been recognised for over 30 years that drug safety depends not only on preclinical studies but also on post-marketing surveillance.6 Post-marketing prescription-event monitoring studies observe large cohorts and aim to provide data on around 10 000 patients for each drug.The data consist of the real life experiences of patients, who are often taking concomitant drugs for other conditions.The first generation antihistamines have been associated with side effects, particularly sedation.1 Second generation antihistamines are therefore favoured over the first generation drugs, not because of greatly improved efficacy but because they have fewer side effects, especially sedation.24 Although the second generation antihistamines are known to all have similar efficacy,3 the extent of their sedative effects is not well established.

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These questionnaires seek to determine any event experienced by patients while they were taking the drug and for a period afterwards.Objectives: To investigate the frequency with which sedation was reported in post-marketing surveillance studies of four second generation antihistamines: loratadine, cetirizine, fexofenadine, and acrivastine. Setting: Prescriptions were obtained for each cohort in the immediate post-marketing period.Subjects: Event data were obtained for a total of 43 363 patients.The data collection periods for the four drugs were May to August 1989 for cetirizine and loratadine, May 1989 to September 1990 for acrivastine, and March to August 1997 for fexofenadine.The response rates (number of green forms returned/number of green form sent) were 50.7% for loratadine, 50.9% for fexofenadine, 56.5% for acrivastine, and 57.4% for cetirizine.

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